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Recent insights into pathophysiology of sepsis-associated liver dysfunction

Journal Volume 64 - 2001
Issue Fasc.4 - Case series
Author(s) M. Adler
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Département Médico-Chirurgical de Gastro-entérologie et d'Hépatopancréatologie, H6pital Erasme - ULB, 808 Route de Lennik, 1070 Brussels, Belgium.

As many of 54% of patients admitted to the Intensive Care Unit (ICU) have abnormal liver function tests (1) and jaundice has been documented in as many as 44% (2) of patients admitted to the ICU because of sepsis, trauma, major surgery, and/or extensive tissue damage. Of these, sepsis appears to be the most common precipitating factor. Severity of jaundice increases with the number of organs failing and correlates with mortality (2). The aim of the present review is to reexamine recent pathophysiological da3

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